Studies on Activity of Tryptophan Aminotransferase in Rat Liver

Tryptophan aminotransferase activity in rat liver.

By using an antiserum raised against rat liver tyrosine aminotransferase, it was shown that about 60% of tryptophan aminotransferase activity in rat liver extracts is catalysed by this enzyme. Induction of tryptophan aminotransferase activity by intraperitoneal injections of tryptophan or triamcinolone can be entirely attributed to the effects of these agents on tyrosine aminotransferase. The o...

Studies on the development of ornithine-keto acid aminotransferase activity in rat liver.

1. During the normal development of the rat, the specific activity of liver ornithine-keto acid aminotransferase exhibits a transient elevation around term, and subsequently increases to adult activity levels during the third postnatal week. 2. The synthetic glucocorticoid triamcinolone, administered as a single injection, produces a marked elevation of the ornithine-keto acid aminotransferase ...

Determination of tryptophan pyrrolase activity in rat liver homogenates.

Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity.

We investigated how changes in tryptophan pyrrolase activity and tryptophan loads affect the breakdown of tryptophan was estimated by injecting rats with [ring-2-14-C]tryptophan and measuring respiratory 14-CO2. We concluded, contrary to previous reports, that induction of tryptophan pyrrolase definitely will increase the rate of tryptophan breakdown. Tryptophan loads also increase tryptophan b...

Tryptophan Catabolism by Tryptophan Pyrrolase in Rat Liver THE EFFECT OF TRYPTOPHAK LOADS AKD CHAKGES IN TRYPTOPHAN PYRROLASE ACTIVITY*

We investigated how changes in tryptophan pyrrolase activity and tryptophan loads affect the breakdown of tryptophan by tryptophan pyrrolase. Breakdown of tryptophan was estimated by injecting rats with [ring-ZJ%]tryptophan and measuring respiratory 14C02. We concluded, contrary to previous reports, that induction of tryptophan pyrrolase definitely will increase the rate of tryptophan breakdown...